Tenofovir Nephrotoxicity: 2011 Update

@article{FernndezFernndez2011TenofovirN2,
  title={Tenofovir Nephrotoxicity: 2011 Update},
  author={B. Fern{\'a}ndez-Fern{\'a}ndez and A. Montoya-Ferrer and A. Sanz and M. S{\'a}nchez-Ni{\~n}o and M. C. Izquierdo and J. Poveda and Valeria Sainz-Prestel and Natalia Ortiz-Martin and Alejandro Parra-Rodriguez and R. Selgas and M. Ruiz-Ortega and J. Egido and A. Ortiz},
  journal={AIDS Research and Treatment},
  year={2011},
  volume={2011}
}
Tenofovir is an acyclic nucleotide analogue reverse-transcriptase inhibitor structurally similar to the nephrotoxic drugs adefovir and cidofovir. Tenofovir is widely used to treat HIV infection and approved for treatment of hepatitis B virus. Despite initial cell culture and clinical trials results supporting the renal safety of tenofovir, its clinical use is associated with a low, albeit significant, risk of kidney injury. Proximal tubular cell secretion of tenofovir explains the accumulation… Expand
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