Tenocytes from Ruptured and Tendinopathic Achilles Tendons Produce Greater Quantities of Type III Collagen than Tenocytes from Normal Achilles Tendons: An in Vitro Model of Human Tendon Healing

@article{Maffulli2000TenocytesFR,
  title={Tenocytes from Ruptured and Tendinopathic Achilles Tendons Produce Greater Quantities of Type III Collagen than Tenocytes from Normal Achilles Tendons: An in Vitro Model of Human Tendon Healing},
  author={Nicola Maffulli and Stanley W. B. Ewen and Stuart W. Waterston and Jacqueline Reaper and Victoria Barrass},
  journal={The American Journal of Sports Medicine},
  year={2000},
  volume={28},
  pages={499 - 505}
}
Type I collagen is the main collagen in tendons; type III collagen is present in small amounts. Ruptured Achilles tendons contain a significantly greater proportion of type III collagen, which predisposes them to rupture. We used an in vitro model to determine whether tenocytes from Achilles tendons that were ruptured (N 22), nonruptured (N 7), tendinopathic (N 12), and fetal (N 8) show different behavior. Samples of Achilles tendon were digested with collagenase and the released tenocytes were… Expand
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