Teneurins: important regulators of neural circuitry.

  title={Teneurins: important regulators of neural circuitry.},
  author={Timothy R. Young and Catherine A. Leamey},
  journal={The international journal of biochemistry & cell biology},
  volume={41 5},
Teneurin (Ten-m/Odz) molecules represent a highly conserved family of four type II transmembrane proteins in vertebrates (Ten-m1-4), which exist as homodimers and undergo homophilic interactions. Each is expressed in distinct, and often interconnected, areas of the developing nervous system. Different Ten-ms have complementary expression patterns. In vitro and in vivo studies support roles for teneurins in promoting neurite outgrowth and cell adhesion. Furthermore, the intracellular domains of… CONTINUE READING