Teneurin-4 promotes cellular protrusion formation and neurite outgrowth through focal adhesion kinase signaling.

@article{Suzuki2014Teneurin4PC,
  title={Teneurin-4 promotes cellular protrusion formation and neurite outgrowth through focal adhesion kinase signaling.},
  author={Nobuharu Suzuki and Tadahiro Numakawa and Joshua Chou and Susana de Vega and Chihiro Mizuniwa and Kaori Sekimoto and Naoki Adachi and Hiroshi Kunugi and Eri Arikawa-Hirasawa and Yoshihiko Yamada and Chihiro Akazawa},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2014},
  volume={28 3},
  pages={1386-97}
}
Teneurin-4 (Ten-4), a transmembrane protein, is highly expressed in the central nervous system; however, its cellular and molecular function in neuronal differentiation remains unknown. In this study, we aimed to elucidate the function of Ten-4 in neurite outgrowth. Ten-4 expression was induced during neurite outgrowth of the neuroblastoma cell line Neuro-2a. Ten-4 protein was localized at the neurite growth cones. Knockdown of Ten-4 expression in Neuro-2a cells decreased the formation of the… CONTINUE READING

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