Tendon xanthomas in familial hypercholesterolemia are associated with a differential inflammatory response of macrophages to oxidized LDL.

@article{Artieda2005TendonXI,
  title={Tendon xanthomas in familial hypercholesterolemia are associated with a differential inflammatory response of macrophages to oxidized LDL.},
  author={Marta Artieda and Ana Cenarro and Corina Junquera and Pilar Lasierra and Mar{\'i}a Jos{\'e} Mart{\'i}nez-Lorenzo and Miguel Pocovi and Fernando Civeira},
  journal={FEBS letters},
  year={2005},
  volume={579 20},
  pages={4503-12}
}
Tendon xanthomas (TX) are pathognomonic lipid deposits commonly found in familial hypercholesterolemia (FH) patients. The aim of this study was to determine whether macrophages from FH patients with TX (TX+) have higher predisposition to foam cells formation after oxidized LDL (oxLDL) overload than those from FH patients without TX (TX-), and if their differential gene expression profile could explain these different phenotypes. Total RNA pools from macrophages from FH patients TX+ and TX- were… CONTINUE READING