Tendon Is Covered by a Basement Membrane Epithelium That Is Required for Cell Retention and the Prevention of Adhesion Formation

@inproceedings{Taylor2011TendonIC,
  title={Tendon Is Covered by a Basement Membrane Epithelium That Is Required for Cell Retention and the Prevention of Adhesion Formation},
  author={Susan H. Taylor and Sarah Al-Youha and Tom van Agtmael and Yinhui Lu and Jason T Wong and Duncan Angus McGrouther and Karl E Kadler},
  booktitle={PloS one},
  year={2011}
}
The ability of tendons to glide smoothly during muscle contraction is impaired after injury by fibrous adhesions that form between the damaged tendon surface and surrounding tissues. To understand how adhesions form we incubated excised tendons in fibrin gels (to mimic the homeostatic environment at the injury site) and assessed cell migration. We noticed cells exiting the tendon from only the cut ends. Furthermore, treatment of the tendon with trypsin resulted in cell extravagation from the… CONTINUE READING

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