Tenatoprazole, a novel proton pump inhibitor with a prolonged plasma half-life: effects on intragastric pH and comparison with esomeprazole in healthy volunteers.

@article{Galmiche2004TenatoprazoleAN,
  title={Tenatoprazole, a novel proton pump inhibitor with a prolonged plasma half-life: effects on intragastric pH and comparison with esomeprazole in healthy volunteers.},
  author={Jean Paul Galmiche and S Bruley des Varannes and Ph. Ducrott'e and Sylvie Sacher-Huvelin and Fabienne Vavasseur and Alain Taccoen and Paola Fiorentini and Michel Homerin},
  journal={Alimentary pharmacology & therapeutics},
  year={2004},
  volume={19 6},
  pages={
          655-62
        }
}
BACKGROUND Proton pump inhibitors control gastric acidity better during the day than at night, when nocturnal acid breakthrough can occur. Tenatoprazole is a novel proton pump inhibitor with a seven-fold longer plasma half-life. Aim : To compare the effects of tenatoprazole 20 mg (T20), tenatoprazole 40 mg (T40) and esomeprazole 40 mg (E40) on intragastric acidity in healthy volunteers. METHODS This randomized, three-period, cross-over study enrolled 18 Helicobacter pylori-negative volunteers… CONTINUE READING

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