Tenascins and inflammation in disorders of the nervous system

  title={Tenascins and inflammation in disorders of the nervous system},
  author={Igor Jakov{\vc}evski and Djordje Miljkovi{\'c} and Melitta Schachner and Pavle R. Andjus},
  journal={Amino Acids},
In vitro and in vivo studies on the role of tenascins have shown that the two paradigmatic glycoproteins of the tenascin family, tenascin-C (TnC) and tenascin-R (TnR) play important roles in cell proliferation and migration, fate determination, axonal pathfinding, myelination, and synaptic plasticity. As components of the extracellular matrix, both molecules show distinct, but also overlapping dual functions in inhibiting and promoting cell interactions depending on the cell type, developmental… CONTINUE READING