Tenascin cytotactin epidermal growth factor‐like repeat binds epidermal growth factor receptor with low affinity

@article{Iyer2007TenascinCE,
  title={Tenascin cytotactin epidermal growth factor‐like repeat binds epidermal growth factor receptor with low affinity},
  author={Anand Krishnan V Iyer and Kien Trung Tran and Christopher W. Borysenko and Michael Cascio and Carlos J. Camacho and Harry C. Blair and Ivet Bahar and Alan Wells},
  journal={Journal of Cellular Physiology},
  year={2007},
  volume={211}
}
Select epidermal growth factor (EGF)‐like (EGFL) repeats of human tenascin cytotactin (tenascin C) can stimulate EGF receptor (EGFR) signaling, but activation requires micromolar concentrations of soluble EGFL repeats in contrast to subnanomolar concentrations of classical growth factors such as EGF. Using in silico homology modeling techniques, we generated a structure for one such repeat, the 14th EGFL repeat (Ten14). Ten14 assumes a tight EGF‐like fold with truncated loops, consistent with… 
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TLDR
A novel class of EGFR ligands are presented that can potentially signal as a part of the matrix, triggering select signaling cascades leading to a directed cellular response from an otherwise pleiotropic receptor.
Cell surface restriction of EGFR by a tenascin cytotactin‐encoded EGF‐like repeat is preferential for motility‐related signaling
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A novel class of EGFR ligands that can potentially signal as a part of the extracellular matrix is presented, triggering specific intracellular signaling cascades leading to a directed cellular response from an otherwise pleiotropic receptor.
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Results suggest that providing MSCs with a nonimmunogenic naturally occurring ECM moiety such as TNC enhances their survival in the presence of death factors, and this advantage occurs via signaling through EGFR primarily and integrins only to a minor extent.
Melanoma cell invasiveness is promoted at least in part by the Epidermal Growth Factor-like repeats of Tenascin-C
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It is suggested that melanoma-derived TNC EGFL play a role in melanoma invasion by modulating ROCK signaling and cell migration and adding TNC to matrices enhances individual melanoma cell migration.
Tenascin-C is expressed by human glioma in vivo and shows a strong association with tumor blood vessels
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Five novel monoclonal antibodies identifying different domains of TN-C are described, finding strong differences between the adhesion-influencing properties of the recombinant fragments on glioma cells.
Engineered Bivalent Ligands to Bias ErbB Receptor-mediated Signaling and Phenotypes*
TLDR
It is demonstrated that bivalent NRG (NN) can bias signaling in HER3-expressing cancer cells, resulting in some cases in decreased migration, inhibited proliferation, and increased apoptosis, whereas native NRG stimulation increased the malignant potential of the same cells.
An extracellular matrix, calmodulin-binding protein from Dictyostelium with EGF-like repeats that enhance cell motility.
The role of tenascin-C in tissue injury and tumorigenesis
TLDR
Hopes are generated that increased knowledge about tenascin-C will further improve management of diseases with high tenascInC expression such as chronic inflammation, heart failure, artheriosclerosis and cancer.
Matricellular Signal Transduction Involving Calmodulin in the Social Amoebozoan Dictyostelium
TLDR
CyrA is the first identified extracellular CaMBP in this eukaryotic microbe and the presence of extCaM and its role in regulating a matricellular protein during morphogenesis extends the understanding of CaM-mediated signal transduction in eukARYotes.
An EGF-like peptide sequence from Dictyostelium enhances cell motility and chemotaxis.
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