Tenascin-X induces cell detachment through p38 mitogen-activated protein kinase activation.

@article{Fujie2009TenascinXIC,
  title={Tenascin-X induces cell detachment through p38 mitogen-activated protein kinase activation.},
  author={Shinpei Fujie and Hiroshi Maita and Hiroyoshi Ariga and Ken-ichi Matsumoto},
  journal={Biological & pharmaceutical bulletin},
  year={2009},
  volume={32 10},
  pages={1795-9}
}
Extracellular matrix glycoprotein tenascin-X (TNX) is the largest member of the tenascin family. In this study, we investigated the adhesive properties of TNX and the signaling pathway to be induced to mouse fibroblast L cells on TNX substrate. Approximately 45% of evaluable cells used in the cell adhesion assay were attached to purified TNX but did not spread and were rounded on TNX. The remaining 55% of cells were detached from the TNX substrate and were floating in the conditioned medium. In… CONTINUE READING