Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro

@article{Scherberich2005TenascinWIF,
  title={Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro},
  author={Arnaud Scherberich and Richard P Tucker and Martin Degen and Marianne Brown-Luedi and A Andr{\'e}s and Ruth Chiquet-Ehrismann},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={1525-1532}
}
Tenascins represent a family of extracellular matrix glycoproteins with distinctive expression patterns. Here we have analyzed the most recently described member, tenascin-W, in breast cancer. Mammary tumors isolated from transgenic mice expressing hormone-induced oncogenes reveal tenascin-W in the stroma around lesions with a high likelihood of metastasis. The presence of tenascin-W was correlated with the expression of its putative receptor, α8 integrin. HC11 cells derived from normal mammary… CONTINUE READING