Tenascin-C is associated with coronary plaque instability in patients with acute coronary syndromes.

@article{Kenji2004TenascinCIA,
  title={Tenascin-C is associated with coronary plaque instability in patients with acute coronary syndromes.},
  author={Kajiwara Kenji and Ueda Hironori and Yamamoto Hideya and Imazu Michinori and Hayashi Yasuhiko and Kohno Nobuoki},
  journal={Circulation journal : official journal of the Japanese Circulation Society},
  year={2004},
  volume={68 3},
  pages={198-203}
}
BACKGROUND Tenascin-C (TNC) is an extracellular matrix glycoprotein that increases after inflammation and injury. In cultured cells TNC has been reported to markedly induce the expression of matrix metalloproteinase-9, which stimulates collagen degradation in the fibrous cap of human atherosclerotic plaque. METHODS AND RESULTS Immunohistochemical techniques were used to analyze the expression of TNC protein in 51 coronary atherectomy specimens obtained from patients with stable angina… CONTINUE READING