Tenascin-C induced signaling in cancer.

  title={Tenascin-C induced signaling in cancer.},
  author={Gertraud Orend and Ruth Chiquet-Ehrismann},
  journal={Cancer letters},
  volume={244 2},
Tenascin-C is an adhesion modulatory extracellular matrix molecule that is highly expressed in the microenvironment of most solid tumors. High tenascin-C expression reduces the prognosis of disease-free survival in patients with some cancers. The possible role of tenascin-C in tumor initiation and progression is addressed with emphasis on underlying signaling mechanisms. How tenascin-C affects malignant transformation, uncontrolled proliferation, angiogenesis, metastasis and escape from tumor… CONTINUE READING

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