Tenascin-C in serum: a questionable tumor marker.

  title={Tenascin-C in serum: a questionable tumor marker.},
  author={Susanne H Schenk and J Muser and Guenter Vollmer and Ruth Chiquet-Ehrismann},
  journal={International journal of cancer},
  volume={61 4},
In normal adult tissue tenascin-C (TN-C) is usually expressed at low levels. However, it is strongly induced in many tumors as well as in other pathological conditions often associated with inflammation. To evaluate the diagnostic significance of TN-C, we established a sensitive sandwich ELISA to determine TN-C levels in serum. Furthermore, we investigated the distribution of TN-C variants in serum and found the large TN-C isoforms to be predominant. We measured TN-C in sera from 15 healthy… CONTINUE READING

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