Tenascin-C contains domains that independently regulate neurite outgrowth and neurite guidance.

@article{Meiners1999TenascinCCD,
  title={Tenascin-C contains domains that independently regulate neurite outgrowth and neurite guidance.},
  author={Sally Meiners and Mary Lynn T. Mercado and M S Nur-e-Kamal and Herbert M Geller},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 19},
  pages={8443-53}
}
Tenascin-C has been implicated in regulation of both neurite outgrowth and neurite guidance. We have shown previously that a particular region of tenascin-C has powerful neurite outgrowth-promoting actions in vitro. This region consists of the alternatively spliced fibronectin type-III (FN-III) repeats A-D and is abbreviated fnA-D. The purpose of this study was to investigate whether fnA-D also provides neurite guidance cues and whether the same or different sequences mediate outgrowth and… CONTINUE READING