Tenascin-C aptamers are generated using tumor cells and purified protein.

  title={Tenascin-C aptamers are generated using tumor cells and purified protein.},
  author={Brian J Hicke and C. Marion and Yi Fang Chang and Ty Gould and Cynthia K Lynott and D L Parma and P. G. Schmidt and S. Warren},
  journal={The Journal of biological chemistry},
  volume={276 52},
Tenascin-C (TN-C) is an extracellular matrix protein that is overexpressed during tissue remodeling processes, including tumor growth. To identify an aptamer for testing as a tumor-selective ligand, SELEX (systematic evolution of ligands by exponential enrichment) procedures were performed using both TN-C and TN-C-expressing U251 glioblastoma cells. The different selection techniques yielded TN-C aptamers that are related in sequence. In addition, a crossover procedure that switched from tumor… CONTINUE READING

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