Tenascin C and tenascin R similarly prevent the formation of myelin membranes in a RhoA-dependent manner, but antagonistically regulate the expression of myelin basic protein via a separate pathway.

@article{Czopka2009TenascinCA,
  title={Tenascin C and tenascin R similarly prevent the formation of myelin membranes in a RhoA-dependent manner, but antagonistically regulate the expression of myelin basic protein via a separate pathway.},
  author={Tim Czopka and Alexander von Holst and Gudula Schmidt and Charles ffrench-Constant and Andreas Faissner},
  journal={Glia},
  year={2009},
  volume={57 16},
  pages={1790-801}
}
Membrane formation and the initiation of myelin gene expression are hallmarks of the differentiation of oligodendrocytes from their precursors. Here, we compared the roles of the two related extracellular matrix (ECM) glycoproteins Tenascin C (Tnc) and Tenascin R (Tnr) in oligodendrocyte differentiation. Oligodendrocyte precursors from Tnr-deficient mice exhibited reduced differentiation, as revealed by retarded expression of myelin basic protein (MBP) in culture. This could be rescued with… CONTINUE READING

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