Ten1p promotes the telomeric DNA-binding activity of Cdc13p: implication for its function in telomere length regulation

@article{Qian2009Ten1pPT,
  title={Ten1p promotes the telomeric DNA-binding activity of Cdc13p: implication for its function in telomere length regulation},
  author={Wei Qian and Jianyong Wang and Na-Na Jin and Xiao-Hong Fu and Yi-Chien Lin and Jing-Jer Lin and Jin-Qiu Zhou},
  journal={Cell Research},
  year={2009},
  volume={19},
  pages={849-863}
}
In Saccharomyces cerevisiae, the essential gene CDC13 encodes a telomeric single-stranded DNA-binding protein that interacts with Stn1p and Ten1p genetically and physically, and is required for telomere end protection and telomere length control. The molecular mechanism by which Ten1 participates in telomere length regulation and chromosome end protection remains elusive. In this work, we observed a weak interaction of Cdc13p and Ten1p in a gel-filtration analysis using purified recombinant… CONTINUE READING

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