Ten ways in which He Jiankui violated ethics

@article{Krimsky2019TenWI,
  title={Ten ways in which He Jiankui violated ethics},
  author={Sheldon Krimsky},
  journal={Nature Biotechnology},
  year={2019},
  volume={37},
  pages={19-20}
}
  • S. Krimsky
  • Published 1 January 2019
  • Psychology, Medicine
  • Nature Biotechnology
1. Roskams-Edris, D., Anderson-Redick, S., Kiss, Z.H. & Illes, J. Nat. Biotechnol. 35, 119–121 (2017). 2. Foster, A.M. et al. US patent 9,327,069 (2006). 3. Wagner, T.A. et al. US patent 9,050,463 (2015). 4. Krueger, R. & Weiss, D. US patent 9,283,378 (2012). 5. Association for Molecular Pathology v. Myriad Genetics, Inc. 569 U.S. 576 (2013). 6. 35 U.S. Code §287(c). 7. United States Constitution, Article I, Section 8, Clause 8. 8. Bonito Boats, Inc. v. Thunder Craft Boats, Inc. 489 U.S. 141… 
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      References

      SHOWING 1-10 OF 11 REFERENCES
      Disease Resistance and the Definition of Genetic Enhancement
      TLDR
      An overview of the key ethical features of CCR5-Δ32 deletion is provided (including its frequency in various populations, biological mechanism, benefits for individuals, and use in previous clinical trials) to offer some potential guideposts for the continuing discussion on how to classify “enhancements” in the age of CRISPR gene editing.
      Draft Ethical Principles for Therapeutic Assisted Reproductive Technologies
      TLDR
      The identification of a core set of fundamental human values to frame, guide, and restrict clinical applications that communities around the world can share and localize based on religious beliefs, culture, and public-health challenges is proposed.
      Should we edit the human germline? Is consensus possible or even desirable?
      • Hastings Center report
      • 2018
      Should we edit the human germline? Is consensus possible or even desirable? Hastings Center report
      • https://www.thehastingscenter.org/edit-humangermline-consensus-possible-even-desirable
      • 2018
      the case of the first gene-edited babies
      • The Conversation
      • 2018
      Global Discussion: 国内留学を目指して
      International Summit on Human Gene Editing: A Global Discussion
      Rogue science strikes again : the case of the first gene - edited babies
      Rogue science strikes again: the case of the first gene-edited babies. The Conversation
      ...
      1
      2
      ...