Ten reasons to be happy about hormone replacement therapy: a guide for patients

@article{Studd2010TenRT,
  title={Ten reasons to be happy about hormone replacement therapy: a guide for patients},
  author={John W. W. Studd},
  journal={Menopause International},
  year={2010},
  volume={16},
  pages={44 - 46}
}
  • J. Studd
  • Published 1 March 2010
  • Medicine
  • Menopause International
In spite of the negative press reports following the 2002 Women's Health Initiative (WHI) publication, women can be reassured that in the correct circumstances, hormone replacement therapy (HRT) is beneficial and safe, particularly if treatment is started below the age of 60. Transdermal estradiol is probably safer than oral estrogens as coagulation factors are not induced in the liver and HRT is safer if a minimal duration and dose of progestogen is used. HRT is effective for the treatment of… 
MPA: medroxy-progesterone acetate contributes to much poor advice for women.
TLDR
This issue extends a multipart investigation on the differences in the neural actions of medroxyprogesterone acetate (MPA) vs. progesterone (P4, pregn-4-ene-3, 20-dione) and focuses on the progestin problem.
Can depression be a menopause-associated risk?
TLDR
An overview of what is known about risk factors for depression and the risk posed by the menopausal transition, its associated symptoms, and the underlying changes in the reproductive hormonal milieu is provided, discussing the evidence for the occurrence of mood symptoms in midlife women and the challenges that face clinicians and health professionals who care for this population.
Skin academy: hair, skin, hormones and menopause - current status/knowledge on the management of hair disorders in menopausal women.
TLDR
There is little evidence to support treatment for hair and skin disorders specifically in post-menopausal women, but the proportion of the female population who are in the post- menopausal age group is rising and the prevalence of these dermatological symptoms is likely to increase.
Vascular resistance of central retinal artery is reduced in postmenopausal women after use of estrogen
TLDR
It is demonstrated that estrogen reduces the vascular resistance of the central retinal artery in postmenopausal women because of a vasodilatory effect.
The meanings of menopause: identifying the bio-psycho-social predictors of the propensity for treatment at menopause
..... i Declaration ..... ii Acknowledgments ..... iii List of tables ..... v List of figures ..... vii Chapter 1: Introduction 1 Chapter 2: What happens at menopause 8 Chapter 3: Coping with
Research resource: Aorta- and liver-specific ERα-binding patterns and gene regulation by estrogen.
TLDR
It is shown that almost all of the genes regulated by 17β-estradiol (E2) differ between mouse aorta and mouse liver, ex vivo, and that this difference is associated with a distinct genomewide distribution of ERα on chromatin.
Medroxyprogesterone acetate antagonizes estrogen up-regulation of brain mitochondrial function.
TLDR
Findings indicate that the effects of MPA differ significantly from the bioenergetic profile induced by progesterone and that, overall, MPA induced a decline in glycolytic and oxidative phosphorylation protein and activity.
Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen
TLDR
An overview of the literature regarding the antiapoptotic effect of oestrogen in IVDD is performed, indicating that oestrogens can effectively alleviate IVDD development by inhibiting the apoptosis of IVD cells.
Beta-estradiol attenuates hypoxic pulmonary hypertension by stabilizing the expression of p27kip1 in rats
TLDR
Results suggest that β-E2 can effectively attenuate PVSR and HPH, and the underlying mechanism may partially be through the increased p27kip1 by inhibiting Skp-2 through Akt signal pathway.
The Endocrinology of the Mammalian Ovary
TLDR
The roles of hormones and paracrine regulators that regulate, or are produced by, the mammalian ovary are emphasized in this chapter as well as aspects of ovarian aging.
...
1
2
...