Ten pitfalls in the proper management of patients with hyponatremia

@article{Filippatos2016TenPI,
  title={Ten pitfalls in the proper management of patients with hyponatremia},
  author={Theodosios D. Filippatos and George Liamis and Moses S. Elisaf},
  journal={Postgraduate Medicine},
  year={2016},
  volume={128},
  pages={516 - 522}
}
ABSTRACT Hyponatremia (serum sodium <135 mEq/L) is a common electrolyte disorder in community or hospitalized patients. Serum sodium levels should be corrected at a proper rate in patients with hyponatremia, since overcorrection of serum sodium levels is related to devastating neurologic consequences, such as the osmotic demyelination syndrome (ODS). However, a number of pitfalls, which could lead to undercorrection or overcorrection of hyponatremia, are common during the treatment of… 
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13 Citations

Pharmacological management of hyponatremia
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The efficacy and side effects of the currently available treatment options for hyponatremia and the differences in the pharmacological approach between the European and USA guidelines are discussed.
Hyponatremia in Patients with Hematologic Diseases
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This review describes the pathophysiology of hyponatremia and discusses thoroughly the contributing factors and mechanisms that may be encountered specifically in patients with hematologic disorders.
Risk factors for overcorrection of severe hyponatremia: a post hoc analysis of the SALSA trial
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In treating patients with symptomatic hyponatremia, individuals with high hypon atremia overcorrection risks were predictable using a novel risk score summarizing baseline information.
MANAGEMENT OF ENDOCRINE DISEASE: Hypothyroidism-associated hyponatremia: mechanisms, implications and treatment.
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The main mechanism for the development of hyponatremia in patients with chronic hypothyroidism is the decreased capacity of free water excretion due to elevated antidiuretic hormone levels, which is mainly attributed to the hyp Timothyroidism-induced decrease in cardiac output.
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TLDR
More than one-third of critically ill patients had hyponatremia and it was related to poor outcome of the critically ill Patients admitted in the Department of Critical Care Medicine, BIRDEM General Hospital.
Electrolyte and Acid–Base Disturbances in End-Stage Liver Disease: A Physiopathological Approach
Electrolyte and acid–base disturbances are frequent in patients with end-stage liver disease; the underlying physiopathological mechanisms are often complex and represent a diagnostic and therapeutic…
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Clinical studies have not shown a greater clinical benefit of albumin solutions compared with crystalloid solutions, and intravenous fluids should be dealt with as drugs, as they have specific clinical indications, contraindications and adverse effects.
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TLDR
Clinicians should choose appropriately between antidiabetic drugs based not only on their hypoglycemic efficacy and effects on cardiovascular risk but also based on the patient’s specific risk to develop acid-base or electrolyte derangements.
Efficacy of Furosemide, Oral Sodium Chloride, and Fluid Restriction for Treatment of Syndrome of Inappropriate Antidiuresis (SIAD): An Open-label Randomized Controlled Study (The EFFUSE-FLUID Trial).
TLDR
In patients with SIAD, furosemide with NaCl supplement in combination with fluid restriction did not show benefits in correction of [Na+] compared with treatment withfluid restriction alone.
Contribution à l'étude du rôle de l’hyponatrémie légère et chronique dans la survenue de la chute grave du sujet âgé fragile admis en unité de Médecine d'Urgence de la Personne Agée (MUPA)
Les chutes a domicile sont un signe precurseur de la perte d’autonomie et representent un probleme majeur de sante publique. La chute implique de multiples facteurs determinant le risque de chute.…
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