Ten families of variant genes encoded in subtelomeric regions of multiple chromosomes of Plasmodium chabaudi, a malaria species that undergoes antigenic variation in the laboratory mouse.

@article{Fischer2003TenFO,
  title={Ten families of variant genes encoded in subtelomeric regions of multiple chromosomes of Plasmodium chabaudi, a malaria species that undergoes antigenic variation in the laboratory mouse.},
  author={Katja Fischer and Marina Chavchich and Robert L. Huestis and Danny W. Wilson and David J. Kemp and A Tova Saul},
  journal={Molecular microbiology},
  year={2003},
  volume={48 5},
  pages={1209-23}
}
The chromosome ends of human malaria parasites harbour many genes encoding proteins that are exported to the surface of infected red cells, often being involved in host-parasite interactions and immune evasion. Unlike other murine malaria parasites Plasmodium chabaudi undergoes antigenic variation during passage in the laboratory mouse and hence is a model suitable for investigation of switching mechanisms. However, little is known about the subtelomeric regions of P. chabaudi chromosomes and… CONTINUE READING

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