Ten eleven translocation enzymes and 5-hydroxymethylation in mammalian development and cancer.


5-Hydroxymethylcytosine (5hmC) is an oxidative product of 5-methylcytosine (5mC), catalyzed by the ten eleven translocation (TET) family of enzymes. Although 5hmC was discovered several decades ago, it was only after its recent identification in murine brain and stem cell DNA that it has become a major focus of epigenomic research. Part of the reason for… (More)
DOI: 10.1007/978-1-4419-9967-2_3