Ten challenges for TB biomarkers.

  title={Ten challenges for TB biomarkers.},
  author={Tom H. M. Ottenhoff and Jerrold J. Ellner and Stefan H. E. Kaufmann},
  volume={92 Suppl 1},
The availability of tuberculosis (TB) biomarkers of protection (or: "surrogate endpoints of protection against active TB" (Biomarkers Definitions Working Group, 2001)) would greatly facilitate and accelerate TB vaccine development and increase the likelihood of success. TB biomarkers of protection could determine which vaccines in clinical trials are the most efficacious; which vaccine candidates and strategies are the most promising in early stages in the preclinical development pipeline… CONTINUE READING

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