Ten and ninety-day toxicity studies of 1,2-dichloroethane in Sprague-Dawley rats.

@article{Daniel1994TenAN,
  title={Ten and ninety-day toxicity studies of 1,2-dichloroethane in Sprague-Dawley rats.},
  author={F. Bernard Daniel and Mervyn Robinson and Greg R. Olson and Raymond G York and L W Condie},
  journal={Drug and chemical toxicology},
  year={1994},
  volume={17 4},
  pages={463-77}
}
Male and female Sprague-Dawley rats received 1,2-dichloroethane in corn oil by gavage for 10 or 90 consecutive days. The doses for the 10-day study were 10, 30, 100, and 300 mg/kg; the 90-day study doses were 37.5, 75, and 150 mg/kg. There were ten animals per sex per dose group. In the 10-day study, all female animals died in the high dose group and only 2 of 10 males survived. Final body weights and weight gain along with hematology and clinical chemistry findings were not different from… CONTINUE READING