Temporin L: antimicrobial, haemolytic and cytotoxic activities, and effects on membrane permeabilization in lipid vesicles.

@article{Rinaldi2002TemporinLA,
  title={Temporin L: antimicrobial, haemolytic and cytotoxic activities, and effects on membrane permeabilization in lipid vesicles.},
  author={Andrea C Rinaldi and Maria Luisa Mangoni and Anna Rufo and Carla Luzi and Donatella Barra and Hongxia Zhao and Paavo K. J. Kinnunen and Argante Bozzi and Antonio Di Giulio and Maurizio Simmaco},
  journal={The Biochemical journal},
  year={2002},
  volume={368 Pt 1},
  pages={91-100}
}
The temporins are a family of small, linear antibiotic peptides with intriguing biological properties. We investigated the antibacterial, haemolytic and cytotoxic activities of temporin L (FVQWFSKFLGRIL-NH2), isolated from the skin of the European red frog Rana temporaria. The peptide displayed the highest activity of temporins studied to date, against both human erythrocytes and bacterial and fungal strains. At variance with other known temporins, which are mainly active against Gram-positive… CONTINUE READING
39 Citations
53 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 53 references

Structural and charge requirements for antimicrobial peptide insertion into biological and model membranes

  • H. X. Zhao, A. C. Rinaldi, A. Rufo, A. Bozzi, P. K. J. Kinnunen, A. Di Giulio
  • Pore - Forming Peptides and Protein Toxins
  • 2002

Effects of temporins on molecular dynamics and membrane permeabilization in lipid vesicles

  • A. Bozzi
  • J. Pept. Res
  • 2001

Synthesis and antimicrobial activity of the symmetric dimeric form of temporin A based on 3-N,N-di(3-aminopropyl)amino propanoic acid as the branching unit

  • R. Laatikainen, A. Narvanen
  • Bioorg. Med. Chem
  • 2001

Similar Papers

Loading similar papers…