Temporary vascular occlusion with poloxamer 407.

@article{Raymond2004TemporaryVO,
  title={Temporary vascular occlusion with poloxamer 407.},
  author={Jean Raymond and Annick Metcalfe and Igor Salazkin and Alexander Schwarz},
  journal={Biomaterials},
  year={2004},
  volume={25 18},
  pages={
          3983-9
        }
}
There is a need for safe and reversible occlusions during percutaneous endovascular procedures. Poloxamer 407 is a non-ionic surfactant with rapid reversible sol-gel transition behaviour. The safety and efficacy of this polymer as a temporary embolic agent was investigated. First, dissolution time after gelation of poloxamer was determined in an in vitro model. Then, transient poloxamer occlusion of renal and pulmonary arteries of seven dogs was followed by serial angiograms. Macroscopic and… CONTINUE READING

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