Temporary reversal of serum to cerebrospinal fluid glycerol concentration gradient after intravenous infusion of glycerol

@article{Nau1992TemporaryRO,
  title={Temporary reversal of serum to cerebrospinal fluid glycerol concentration gradient after intravenous infusion of glycerol},
  author={Roland Nau and F.-J. Prins and Herbert Kolenda and Hilmar W. Prange},
  journal={European Journal of Clinical Pharmacology},
  year={1992},
  volume={42},
  pages={181-185}
}
Glycerol 50 g infused i. v. over 2 to 6 h is widely used to treat cerebral oedema in patients with acute stroke. Its transit through the blood-cerebrospinal fluid barrier in subjects with uninflamed meninges has now been examined. In 7 patients with an external ventriculostomy for occlusive hydrocephalus, each of whom was given 500 ml of a 10% solution IV over 4 h, serum and CSF were repeatedly sampled during and after the infusion and glycerol was measured enzymatically. The highest serum… CONTINUE READING