Temporary inactivation of the nucleus accumbens disrupts acquisition and expression of fear-potentiated startle in rats

@article{Schwienbacher2004TemporaryIO,
  title={Temporary inactivation of the nucleus accumbens disrupts acquisition and expression of fear-potentiated startle in rats},
  author={Isabel Schwienbacher and Markus Fendt and Rick Richardson and Hans-Ulrich Schnitzler},
  journal={Brain Research},
  year={2004},
  volume={1027},
  pages={87-93}
}
Recent research suggests that in addition to its prominent role in appetitive learning, the nucleus accumbens (NAC) may also be involved in fear conditioning. In the present study, we investigated whether temporary inactivation of the NAC, by injection of tetrodotoxin (TTX), affects acquisition and expression of conditioned fear, as measured by fear-potentiated startle (FPS). TTX injection into the NAC totally blocked acquisition and markedly decreased expression of conditioned fear to a… Expand
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