Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques.

@article{McDannold2012TemporaryDO,
  title={Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques.},
  author={Nathan J. McDannold and Costas D. Arvanitis and Natalia Vykhodtseva and Margaret S. Livingstone},
  journal={Cancer research},
  year={2012},
  volume={72 14},
  pages={3652-63}
}
The blood-brain barrier (BBB) prevents entry of most drugs into the brain and is a major hurdle to the use of drugs for brain tumors and other central nervous system disorders. Work in small animals has shown that ultrasound combined with an intravenously circulating microbubble agent can temporarily permeabilize the BBB. Here, we evaluated whether this targeted drug delivery method can be applied safely, reliably, and in a controlled manner on rhesus macaques using a focused ultrasound system… CONTINUE READING