Temporally precise in vivo control of intracellular signalling

@article{Airan2009TemporallyPI,
  title={Temporally precise in vivo control of intracellular signalling},
  author={R. Airan and K. Thompson and Lief E Fenno and Hannah Bernstein and K. Deisseroth},
  journal={Nature},
  year={2009},
  volume={458},
  pages={1025-1029}
}
In the study of complex mammalian behaviours, technological limitations have prevented spatiotemporally precise control over intracellular signalling processes. Here we report the development of a versatile family of genetically encoded optical tools (‘optoXRs’) that leverage common structure–function relationships among G-protein-coupled receptors (GPCRs) to recruit and control, with high spatiotemporal precision, receptor-initiated biochemical signalling pathways. In particular, we have… Expand
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