Temporally expressed PDGF and FGF-2 regulate embryonic coronary artery formation and growth.

Abstract

OBJECTIVE PDGF and FGF-2 are important regulators of vascular wall assembly. We tested the hypothesis that their embryonic temporal expression facilitates 2 specific events: (1) the endothelial invasion of the aortic root to form the coronary artery stems and (2) the subsequent growth and development of the arterial tree. METHODS AND RESULTS Addition of… (More)
DOI: 10.1161/ATVBAHA.108.166454

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