Temporally and spatially regulated somatic mutagenesis in mice.

@article{Schwenk1998TemporallyAS,
  title={Temporally and spatially regulated somatic mutagenesis in mice.},
  author={Frieder Schwenk and Rotraud Kuhn and Pierre-Olivier Angrand and K. Rajewsky and Adrian Francis Stewart},
  journal={Nucleic acids research},
  year={1998},
  volume={26 6},
  pages={1427-32}
}
In mice transgenesis through oocyte injection or DNA recombination in embryonal stem (ES) cells allows mutations to be introduced into the germline. However, the earliest phenotype of the introduced mutation can eclipse later effects. We show in mice that site-specific genomic recombination can be induced in a selected cell type, B lymphocytes, at a chosen time. This precision of somatic mutagenesis was accomplished by limiting expression of a Cre recombinase-estrogen receptor fusion protein to… CONTINUE READING

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