Temporally Distinct PD-L1 Expression by Tumor and Host Cells Contributes to Immune Escape.

  title={Temporally Distinct PD-L1 Expression by Tumor and Host Cells Contributes to Immune Escape.},
  author={Takuro Noguchi and Jeffrey P. Ward and Matthew M. Gubin and Cora D. Arthur and Sang Hun Lee and Jasreet Hundal and Mark Selby and Robert F. Graziano and Elaine R. Mardis and Alan J Korman and Robert D Schreiber},
  journal={Cancer immunology research},
  volume={5 2},
Antibody blockade of programmed death-1 (PD-1) or its ligand, PD-L1, has led to unprecedented therapeutic responses in certain tumor-bearing individuals, but PD-L1 expression's prognostic value in stratifying cancer patients for such treatment remains unclear. Reports conflict on the significance of correlations between PD-L1 on tumor cells and positive clinical outcomes to PD-1/PD-L1 blockade. We investigated this issue using genomically related, clonal subsets from the same methylcholanthrene… CONTINUE READING
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Radiation and dual on January 12, 2017

  • CT-S Victor, AJ Rech, A Maity, R Rengan, KE Pauken, E Stelekati
  • Author Manuscript Published OnlineFirst on…
  • 2017
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