Temporal usage of multiple promoters during the life cycle of human papillomavirus type 31b.

@article{Ozbun1998TemporalUO,
  title={Temporal usage of multiple promoters during the life cycle of human papillomavirus type 31b.},
  author={Michelle A. Ozbun and Craig Meyers},
  journal={Journal of virology},
  year={1998},
  volume={72 4},
  pages={2715-22}
}
The life cycles of human papillomaviruses (HPVs) are dependent upon the differentiation of the epithelial cells they infect. HPV type 31b (HPV31b) virions can be purified following the growth of a latently HPV-infected cell line (CIN-612 9E) in the organotypic or raft system. Treatment of the CIN-612 9E raft tissues with protein kinase C (PKC) activators is required for upregulation of late gene expression and efficient production of virions. We employed the raft culture system to study the… CONTINUE READING
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