Temporal uncoupling of the DNA methylome and transcriptional repression during embryogenesis.

  title={Temporal uncoupling of the DNA methylome and transcriptional repression during embryogenesis.},
  author={Ozren Bogdanovi{\'c} and Steven W Long and Simon J van Heeringen and Arie B. Brinkman and Jos{\'e} Luis G{\'o}mez-Skarmeta and Hendrik G. Stunnenberg and Peter L Jones and Gert Jan C. Veenstra},
  journal={Genome research},
  volume={21 8},
DNA methylation is a tightly regulated epigenetic mark associated with transcriptional repression. Next-generation sequencing of purified methylated DNA obtained from early Xenopus tropicalis embryos demonstrates that this genome is heavily methylated during blastula and gastrula stages. Although DNA methylation is largely absent from transcriptional start sites marked with histone H3 lysine 4 trimethylation (H3K4me3), we find both promoters and gene bodies of active genes robustly methylated… CONTINUE READING
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