Temporal trends in prognostic markers of HIV-1 virulence and transmissibility: an observational cohort study.

@article{Pantazis2014TemporalTI,
  title={Temporal trends in prognostic markers of HIV-1 virulence and transmissibility: an observational cohort study.},
  author={Nikos Pantazis and Kholoud Porter and Dominique Costagliola and Andrea De Luca and Jade Ghosn and Marguerite Guiguet and Anne M Johnson and Anthony D. Kelleher and Charles S Morrison and Rodolphe Thi{\'e}baut and Linda Wittkop and Giota Touloumi},
  journal={The lancet. HIV},
  year={2014},
  volume={1 3},
  pages={
          e119-26
        }
}
BACKGROUND Measures of CD4 T-cell count and HIV-1 plasma viral load before antiretroviral therapy are proxies for virulence. Whether these proxies are changing over time has implications for prevention and treatment. The aim of this study was to investigate those trends. METHODS Data were derived from the Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) collaboration of mainly European seroconverter cohorts. Longitudinal CD4 cell counts and plasma viral load… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

Impact of HIV-1 subtype on CD4 count at HIV seroconversion, rate of decline, and viral load set point in European seroconverter cohorts.

Diff erences in HIV natural history among African and non - African seroconverters in Europe and seroconverters in sub - Saharan Africa

  • N Pantazis, G Touloumi
  • PLoS One
  • 2012

HIV natural history among African and non-African seroconverters in Europe and seroconverters in sub-Saharan Africa

  • N Pantazis, G. Touloumi
  • PLoS One 2012;
  • 2012