Temporal requirements of heat shock factor-1 for longevity assurance.

@article{Volovik2012TemporalRO,
  title={Temporal requirements of heat shock factor-1 for longevity assurance.},
  author={Yuli Volovik and Moria Maman and Tatyana Dubnikov and Michal Bejerano-Sagie and Derek Christopher Joyce and Erik A Kapernick and Ehud Cohen and Andrew G Dillin},
  journal={Aging cell},
  year={2012},
  volume={11 3},
  pages={491-9}
}
Reducing the activity of the insulin/IGF-1 signaling pathway (IIS) modifies development, elevates stress resistance, protects from toxic protein aggregation (proteotoxicity), and extends lifespan (LS) of worms, flies, and mice. In the nematode Caenorhabditis elegans, LS extension by IIS reduction is entirely dependent upon the activity of the transcription… CONTINUE READING