Temporal requirement for epidermal growth factor and insulin in the stimulation of hepatocyte DNA synthesis.

@article{Sand1987TemporalRF,
  title={Temporal requirement for epidermal growth factor and insulin in the stimulation of hepatocyte DNA synthesis.},
  author={Tuebingen Sand and Thoralf Christoffersen},
  journal={Journal of cellular physiology},
  year={1987},
  volume={131 2},
  pages={141-8}
}
Primary monolayer cultures of adult rat hepatocytes were used to study the temporal interaction of epidermal growth factor (EGF) and insulin in their stimulation of DNA synthesis. The hepatocytes were cultured both under defined conditions and with serum. EGF and insulin interacted synergistically. The entry into S phase (G1 exit) followed first-order kinetics both in untreated and hormone-stimulated cells. Addition of EGF and insulin at the time of plating did not alter the lag period before… CONTINUE READING

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