Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome.

@article{Wang2004TemporalRO,
  title={Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome.},
  author={Wei Wang and S. Chen and I-Jung Liu and Chuan-Liang Kao and Hui-ling Chen and Bor-Liang Chiang and Jann-Tay Wang and Wang-Hwei Sheng and Po Ren Hsueh and Chao-Fu Yang and Pan-Chyr Yang and S -S Chang},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2004},
  volume={39 7},
  pages={1071-5}
}
Although viral replication and overwhelming immune responses are believed to contribute to the progression of severe acute respiratory syndrome (SARS), little is known about the temporal relationship between viral load, ribavirin, proinflammatory cytokines, and clinical progression. We report that ribavirin was not effective in reducing the SARS coronavirus load in 3 of 8 probable cases studied and that elevated levels of interleukin (IL)-6 and IL-8 subsequent to the peak viral load were found… CONTINUE READING

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