Temporal relationship between endothelin-1 concentrations and cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.

@article{Mascia2001TemporalRB,
  title={Temporal relationship between endothelin-1 concentrations and cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.},
  author={Luciana Mascia and Ludvik Fedorko and Dr. Julian Stewart and Fredj Mohamed and K G terBrugge and V. Marco Ranieri and Mark C. Wallace},
  journal={Stroke},
  year={2001},
  volume={32 5},
  pages={1185-90}
}
BACKGROUND AND PURPOSE Endothelin 1 (ET-1) is a potent vasoconstrictor that may play a role in cerebral vasospasm following subarachnoid hemorrhage (SAH). However, data regarding its pathogenic role in the development of vasospasm are controversial. We planned a prospective, observational clinical study to investigate the temporal relationship between increased ET-1 production and cerebral vasospasm or other neurological sequelae after SAH. METHODS ET-1 levels in cerebrospinal fluid (CSF… CONTINUE READING