Temporal regulation of topoisomerase IV activity in E. coli.

@article{Espli2003TemporalRO,
  title={Temporal regulation of topoisomerase IV activity in E. coli.},
  author={Olivier Esp{\'e}li and Cindy B Levine and Heide Hassing and Kenneth J. Marians},
  journal={Molecular cell},
  year={2003},
  volume={11 1},
  pages={189-201}
}
We isolated a mutant allele of dnaX, encoding the tau and gamma subunits of the DNA polymerase III holoenzyme, that causes extreme cell filamentation but does not affect either cell growth or DNA replication. This phenotype results from a defect in daughter chromosome decatenation during rapid growth. In these cells, ParC, one subunit of topoisomerase IV, no longer associated with the replication factory, as occurs in wild-type cells, and was instead distributed uniformly on the nucleoid; the… CONTINUE READING

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