Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells

@article{Wu2016TemporalRO,
  title={Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells},
  author={Jung-Lin Wu and Hsin‐Yi Wu and Dong-Yan Tsai and Ming-Feng Chiang and Yi‐Ju Chen and Shijay Gao and Chun‐Cheng Lin and Chun-Hung Lin and Kay-Hooi Khoo and Yu‐Ju Chen and Kuo-I Lin},
  journal={Nature Communications},
  year={2016},
  volume={7}
}
Crosslinking of B-cell receptor (BCR) sets off an apoptosis programme, but the underlying pathways remain obscure. Here we decipher the molecular mechanisms bridging B-cell activation and apoptosis mediated by post-translational modification (PTM). We find that O-GlcNAcase inhibition enhances B-cell activation and apoptosis induced by BCR crosslinking. This proteome-scale analysis of the functional interplay between protein O-GlcNAcylation and phosphorylation in stimulated mouse primary B cells… 
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