Temporal profiling of the transcriptional basis for the development of corticosteroid-induced insulin resistance in rat muscle.

@article{Almon2005TemporalPO,
  title={Temporal profiling of the transcriptional basis for the development of corticosteroid-induced insulin resistance in rat muscle.},
  author={Richard R. Almon and Debra C. DuBois and Jin Yan Jin and William J. Jusko},
  journal={The Journal of endocrinology},
  year={2005},
  volume={184 1},
  pages={219-32}
}
Elevated systemic levels of glucocorticoids are causally related to peripheral insulin resistance. The pharmacological use of synthetic glucocorticoids (corticosteroids) often results in insulin resistance/type II diabetes. Skeletal muscle is responsible for close to 80% of the insulin-induced systemic disposal of glucose and is a major target for glucocorticoid-induced insulin resistance. We used Affymetrix gene chips to profile the dynamic changes in mRNA expression in rat skeletal muscle in… CONTINUE READING
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