Temporal profiles of high-mobility group box 1 expression levels after cortical spreading depression in mice.

@article{Takizawa2016TemporalPO,
  title={Temporal profiles of high-mobility group box 1 expression levels after cortical spreading depression in mice.},
  author={Tsubasa Takizawa and Mamoru Shibata and Yohei Kayama and Haruki Toriumi and Taeko Ebine and Anri Koh and Toshihiko Shimizu and Norihiro Suzuki},
  journal={Cephalalgia : an international journal of headache},
  year={2016},
  volume={36 1},
  pages={
          44-52
        }
}
INTRODUCTION Cortical spreading depression (CSD) has recently been shown to induce the release of the nuclear protein termed high-mobility group box 1 from neurons, causing activation of the trigeminovascular system. Here, we explored the effects of single and multiple cortical spreading depression inductions on high-mobility group box 1 (HMGB1) transcriptional activity relative to high-mobility group box 1 protein expression levels and intracellular localization in cortical neurons and… CONTINUE READING

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