Temporal profile of potassium channel dysfunction in cerebrovascular smooth muscle after experimental subarachnoid haemorrhage.

@article{Jahromi2008TemporalPO,
  title={Temporal profile of potassium channel dysfunction in cerebrovascular smooth muscle after experimental subarachnoid haemorrhage.},
  author={B S Jahromi and Yasuo Aihara and Jinglu Ai and Z. D. Zhang and George Weyer and Elena Nikitina and Reza Yassari and Khaled M Houamed and Robert L Macdonald},
  journal={Neuroscience letters},
  year={2008},
  volume={440 1},
  pages={81-6}
}
The pathogenesis of cerebral vasospasm after subarachnoid haemorrhage (SAH) involves sustained contraction of arterial smooth muscle cells that is maximal 6-8 days after SAH. We reported that function of voltage-gated K+ (KV) channels was significantly decreased during vasospasm 7 days after SAH in dogs. Since arterial constriction is regulated by membrane potential that in turn is determined predominately by K+ conductance, the compromised K+ channel dysfunction may cause vasospasm. Additional… CONTINUE READING