Temporal production of the signaling lipid phosphatidic acid by phospholipase D2 determines the output of extracellular signal-regulated kinase signaling in cancer cells.

@article{Zhang2014TemporalPO,
  title={Temporal production of the signaling lipid phosphatidic acid by phospholipase D2 determines the output of extracellular signal-regulated kinase signaling in cancer cells.},
  author={Feng Zhang and Ziqing Wang and Maryia Lu and Yoshiya Yonekubo and Xiao Liang and Yueqiang Zhang and Ping Wu and Yong Zhou and Sergio Grinstein and John F Hancock and Guangwei Du},
  journal={Molecular and cellular biology},
  year={2014},
  volume={34 1},
  pages={
          84-95
        }
}
The Ras-extracellular signal-regulated kinase (ERK) cascade is an important signaling module in cells. One regulator of the Ras-ERK cascade is phosphatidic acid (PA) generated by phospholipase D (PLD) and diacylglycerol kinase (DGK). Using a newly developed PA biosensor, PASS (phosphatidic acid biosensor with superior sensitivity), we found that PA was generated sequentially by PLD and DGK in epidermal growth factor (EGF)-stimulated HCC1806 breast cancer cells. Inhibition of PLD2, one of the… CONTINUE READING
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