Temporal processes of formalin pain: differential role of the cingulum bundle, fornix pathway and medial bulboreticular formation

@article{Vaccarino1992TemporalPO,
  title={Temporal processes of formalin pain: differential role of the cingulum bundle, fornix pathway and medial bulboreticular formation},
  author={Anthony L. Vaccarino and Ronald Melzack},
  journal={Pain},
  year={1992},
  volume={49},
  pages={257-271}
}
Subcutaneous injection of formalin produces a characteristic biphasic pain response. An early phase develops in the first 5 min after injection; the pain then decreases for 10-15 min, followed by a gradual rise to a stable plateau that lasts about 1 h. Rats were injected with 1 microliter of 2% lidocaine or saline into the anterior cingulum bundle at 0 (immediately), 10 or 30 min prior to formalin injection, or 10, 20 or 30 min after formalin injection, and tested for analgesia in the late… CONTINUE READING

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