Temporal patterns of bone marrow cell differentiation following transplantation in doxorubicin-induced cardiomyopathy.

@article{Agbulut2003TemporalPO,
  title={Temporal patterns of bone marrow cell differentiation following transplantation in doxorubicin-induced cardiomyopathy.},
  author={Onnik Agbulut and Marie-Laurence Menot and Zhenlin Li and Françoise Marotte and Denise Paulin and Albert Hagege and Christine Chomienne and J K A Samuel and Philippe Menasch{\'e}},
  journal={Cardiovascular research},
  year={2003},
  volume={58 2},
  pages={451-9}
}
OBJECTIVE Recent studies have suggested benefits of bone marrow cell transplantation for the regeneration of ischemic cardiac tissue. To extend the potential of cell transplantation, we assessed this treatment in a mouse model of acute nonischemic doxorubicin-induced cardiomyopathy. METHODS To allow detection of engrafted cells, we used transgenic mice expressing the nuclear-located LacZ under the control of either desmin or vimentin promoters, which identify muscle lineage and mesenchymal… CONTINUE READING