Temporal pattern of NFkappaB activation influences apoptotic cell fate in a stimuli-dependent fashion.

@article{Fan2002TemporalPO,
  title={Temporal pattern of NFkappaB activation influences apoptotic cell fate in a stimuli-dependent fashion.},
  author={Chenguang Fan and Jusan Yang and John F. Engelhardt},
  journal={Journal of cell science},
  year={2002},
  volume={115 Pt 24},
  pages={4843-53}
}
The transcription factor NFkappaB is a critical immediate early response gene involved in modulating cellular responses and apoptosis following diverse environmental injuries. The activation of NFkappaB is widely accepted to play an anti-apoptotic role in cellular responses to injury. Hence, enhancing NFkappaB activation in the setting of injury has been proposed as one potential therapeutic approach to environmental injuries. To this end, we constructed a recombinant adenoviral vector (Ad… CONTINUE READING

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